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Robert Langer presents a report on the use of Vitamin E, a popular anti-oxidant supplement, and weighs recent evidence on the safety of Vitamin E. Are typical doses in supplements dangerous? Dr. Robert Langer, professor of family and preventive medicine and principal investigator of a large study testing whether Vitamin E prevents prostate cancer, provides an overview of the controversy. Series: "Health Sciences Journal" [3/2005] [Health and Medicine] [Show ID: 9267]
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Vitamin E has been shown to enhance oxygen utilization during exercise at altitude [17], but does not appear to be an effective ergogenic under sea level conditions [18]. A contemporary review indicated that although vitamin E supplementation may increase tissue or serum vitamin E concentration, most evidence suggests there is no discernable effect on training, performance, or rate of post-exercise recovery in either recreational or elite athletes [19]. CoQ10, also known as ubiquinone, is an antioxidant and may improve oxygen uptake in the mitochondria of the heart, and has been used therapeutically for the treatment of cardiovascular disease. Theoretically, improved oxygen usage in the heart and skeletal muscles could improve aerobic endurance performance. Only limited data are available, but these studies have shown that CoQ10 supplementation to healthy young or older subjects did not influence lipid peroxidation, heart rate, maximal oxygen uptake, anaerobic threshold, or cycling endurance performance [20-23]. One study reported that CoQ10 supplementation was associated with muscle tissue damage and actually impaired cycling performance compared to the placebo treatment [24]. Overall, a recent review [25] concluded that there is limited evidence that dietary supplementation with antioxidants improves human performance.
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